The most common group of 3 genes inherited is CDe with ce (D negative) being the second most common. The Fisher-Race system, the nomenclature used most commonly, uses the CDE system to depict the notation of Rh genotypes (Race 1948). Together, these antigens form the most complex and polymorphic blood group system based on the multitude of phenotypes that can be expressed on the RBC surface. The remaining antigens are produced by partial deletion, recombination, mutation, or polymorphisms of one or both RHD and RHCE genes (Cartron 1999). These polypeptides are the core components of their respective antigens but by themselves are devoid of the immunoreactivity which defines the Rh antigens. The RHCE gene produces polypeptides with C/c and E/e antigens. Anti-D antibodies are only seen if an individual is lacking the D antigen (Rh-) and is exposed to Rh+ blood. Importantly, if individuals are Rh+ and are exposed to Rh- blood, no immune response is mounted. Once exposed, however, Rh+ individuals remain sensitive for the rest of their lives. Some believe Rh-negative blood is simply a mutation that came about at some unknown time in our evolution. Humans are not born with antibodies towards the D antigen in their blood, they have to be exposed to it (through blood transfusion or placental exposure during pregnancy) at some point in their lives before antibodies are made against it. The term "Rh factor" refers only to the D antigen Rh positive (Rh+) individuals have the D antigen on their RBC membranes whereas Rh negative (Rh-) individuals don't. The RHD gene produces the D antigen, the most immunogenic Rh antigen. Rh antigens are expressed on red cell (RBC) membranes in association with other membrane proteins and this whole complex interacts with the spectrin-based skeleton and contributes to the maintenance of the mechanical properties of the RBC membrane (Van Kim et al. Of the 50 defined Rh blood group antigens, five (D, C/c and E/e) are the major types expressed by the RHD and RHCE genes in the RH gene complex. Subsequent studies by them and Philip Levine and Rufus Stetson identified the antigen that induced this immunization as the "Rh factor" and also its association with hemolytic disease of the newborn (Levine & Stetson 1984, Landsteiner & Wiener 1941). What it also means is that if your babys blood (even a small amount) gets in touch with yours blood, you may develop an allergic reaction. Your body may produce antibodies to an Rh-positive baby if you are Rh-negative. Wiener who named it after the rhesus macaque whose RBCs were used to generate the rabbit immune serum that first detected the human blood group system. The RH Negative blood types have been extensively controlled and manipulated for attempted hijacking by the Illuminati Bloodlines, many insist that reptilians are the source of RH negative blood which is incorrect. If you are A-negative blood type, you need to know a few things, especially when you are pregnant. The Rh blood type was first discovered in 1937 by Karl Landsteiner and Alexander S. The Rhesus (Rh) blood group system (including the Rh factor) is the second most important blood group system after the ABO blood group system.